CBD: Your Best Bud, Or Just A Dud?

On this week’s episode of the podcast, we tackle something that is growing rapidly in popularity—CBD—but does it live up to its hype?

We set the stage by discussing the different forms of CBD and the ways we can ingest it. We dive into the claims made by CBD companies, including that it can help with skin conditions, mental health, and even chronic diseases. Then we do a little microbiology refresher on the chemical makeup of CBD, and differentiate it from its cousin, THC. We talk a bit about hemp-derived CBD versus marijuana-derived CBD, and some of the legal issues surrounding the production and sale of CBD products. We discuss the effects of CBD on our body and consciousness and the reasons why some people use CBD. Next, we do a deep dive on the available research on CBD’s effectiveness for a variety of outcomes, as well as the limitations of the current evidence. We even talk about CBD’s use among dogs and cats! We discuss FDA regulation of CBD (rather, lack thereof) and how there is only one FDA-approved CBD-based drug on the market. We cover a lot of ground in this episode—you don’t want to miss it!

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PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional.

Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance.

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Resources

• CBD Is Everywhere, but Scientists Still Don’t Know Much About It

• Cannabis in Asia: its Center of Origin and Early Cultivation, Based on a Synthesis of Subfossil Pollen and Archaeobotanical Studies

• Cannabis (Marijuana) and Cannabinoids: What You Need To Know

• Cannabidiol (CBD): What We Know and What We Don't

• Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence

• Efficacy, Tolerability and Safety of Cannabis-Based Medicines for Chronic Pain Management– An Overview of Systematic Reviews

• Cannabidiol (CBD) Use in Psychiatric Disorders; A Systematic Review

• Cannabidiol Presents an Inverted U-Shaped Dose-Response Curve in a Simulated Public Speaking Test

• Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders

• Antidepressant-Like Effect Induced by Cannabidiol is Dependent on Brain Serotonin Levels

• Cannabis for the Treatment of Epilepsy: an Update

• FDA Approves First Drug Comprised of an Active Ingredient Derived from Marijuana to Treat Rare, Severe Forms of Epilepsy

• EPIDIOLEX: A Treatment Innovation

• The Role of Cannabinoids In Epilepsy Treatment: a Critical Review of Efficacy Results From Clinical Trials

• Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

• Evaluating Cannabidiol (CBD) Expectancy Effects on Acute Stress and Anxiety in Healthy Adults: A Randomized Crossover Study

• The Effects of Cannabidiol and Analgesic Expectancies on Experimental Pain Reactivity in Healthy Adults: A Balanced Placebo Design Trial

• The Path to the First FDA-Approved Cannabis-Derived Treatment and What Comes Next

• Potent Inhibition of Human Cytochrome P450 3A Isoforms by Cannabidiol: Role of Phenolic Hydroxyl Groups in the Resorcinol Moiety

• What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD

• A Randomized, Double-Blind, Placebo-Controlled Study of Daily Cannabidiol for the Treatment of Canine Osteoarthritis Pain

• Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs

• Safety and Tolerability of Escalating Cannabinoid Doses in Healthy Cats

• CBD Oil for Cats: What You Need to Know

• FAQs about CBD Use in Pets

• CBD can interact with the following medications. This list is not exhaustive. There may be other medications that interact with CBD that have not yet been studied.

  • Lithium

  • Carbamazepine (Tegretol)

  • Citalopram (Celexa)

  • Topiramate (Topomax)

  • Valproic acid (Depakene)

  • Methadone (Methadose)

  • Eslicarbazepine (Aptiom)

  • Clobazam (Onfi)

  • Everolimus (Zostress)

  • Brivaracetam (Briviact)

  • Sirolimus (Rapamune)

  • Stiripentol (Diacomit)

  • Tamoxifen (Soltamox)

  • Tacrolimus (Prograf)

  • Warfarin (Coumadin)

  • Zonisamide (Zonegran)

CBD Molecular Structure